STELFONTA®, An Innovative and Effective Treatment for Canine Mast Cell Tumours
Dr Pam Jones DVM DACVIM DACVR
Which one of the following statements describes Stelfonta’s innovative mode of action?
Correct Answer - (c)
a) Long-lasting responses are generated due to the development of anti-tumour memory, otherwise known as immunotherapy
b) It’s a chemotherapy drug that works by preventing the tumour cells from growing, dividing and making more cells.
c) Stelfonta destroys mast cell tumours via an innovative three fold mechanism that induces an acute inflammatory response, an oncolytic effect on the tumour cells and directly destroys tumour vasculature.
Which one of the following statements is TRUE for Stelfonta?
Correct Answer -(a)
a) Stelfonta works rapidly to cause oncolysis of tumour cells within the first hours of treatment by causing disruption of mitochondrial function and tumour cell membranes.
b) It effectively normalises tumour vasculature and attenuates blood vessel growth otherwise known as anti-angiogenic activity.
Stelfonta is a reliable non-surgical treatment for mast cell tumours with 75% of MCTs removed with just one treatment and 87% with one or two treatments. True or False?
Correct Answer -(a)
a) True
b) False
Which one of the following statements best describes Stelfonta’s licensed indications?
Correct Answer -(c)
a) Stelfonta is only indicated for small mast cell tumours below the elbow in dogs.
b) I can only use Stelfonta on a mast cell tumour that is recurrent.
c) It is indicated for non-metastatic cutaneous mast cell tumours (anywhere) and non-metastatic subcutaneous mast cell tumours located at or distal to the elbow/hock in dogs,of any cytological grade, </= 10 cc, accessible to intratumoral injections
Which one of the following options is most correct for the Stelfonta treatment regimen?
Correct Answer -(d)
a) Administration of concomitant medications is essential for two days prior to Day 1 of Stelfonta treatment
b) The dose of Stelfonta on the day of treatment is determined by the volume of the mast cell tumour and not the weight of the dog.
c) The maximum dose of Stelfonta is 0.25mL/kg body weight, with no more than 5mL administered per dog, regardless of tumour volume or dog body weight.
d) All of the above.
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