It is predicated that 14 million newborns globally will be affected by SCD between 2010 & 2050.

All correct - these are some of the organ damage resulting from living with SCD into adulthood

Foetal haemoglobin (HbF) is an “anti-sickling” haemoglobin that is present before birth in the red blood cells. After birth, the gene that makes foetal haemoglobin turns off, which mostly stops the production of foetal haemoglobin. More foetal haemoglobin in the blood can mean fewer episodes of sickling and pain.
Most therapies including gene editing are based on the simple aim to increase the production of HbF

Sickle cell disease is caused by a mutation in the haemoglobin-Beta gene found on chromosome 11. Haemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal haemoglobin (haemoglobin-A) are smooth and round and glide through blood vessels.

Vitamin D is responsible for increasing the absorption of calcium to increase bone density.

Although strenuous exercise can reduce oxygen intake, however mild to moderate exercise increases blood circulation which is beneficial.

All 4 responses are acceptable