Assessment: The Coagulation System
Thank you for completing the Coagulation System material! Now you will be presented with 4 multiple-choice questions. To pass this assessment and receive your certifications you must achieve a score of at least 75%. Good luck!
Laboratory screening for the presence of DOACs can be difficult, due to varying assay sensitivities and availability of screening tests. Which is the most sensitive laboratory test to rule out the presence of dabigatran.
The thrombin time is highly sensitive to direct anti factor IIa therapy. Neither the PT nor APTT are sufficiently sensitive to reliably rule out the presence of DOACs.
References: Gosselin RC, Adcock DM, Bates SM et al. International Council for Standardization in Haematology (ICSH) recommendation for laboratory measurement of direct oral anticoagulants. Thromb Haemost 2018; 18:437-450
Conway SE, Hwang AY, Ponte CD, et al. Laboratory and clinical monitoring of direct acting oral anticoagulants: What clinicians need to know. Pharmacotherapy 2017; 37:236-24
DOACS interfere with in vitro coagulation testing. Which of the following is a true statement about the effects of direct F Xa inhibitors?
DOACS interfere with clot-based coagulation testing, causing falsely decreased procoagulant factor levels and falsely increased levels of anticoagulant proteins. DOACS also interfere with lupus anticoagulant testing, causing false positive results.
References: Gosselin RC, Adcock DM, Bates SM et al. International Council for Standardization in Haematology (ICSH) recommendation for laboratory measurement of direct oral anticoagulants. Thromb Haemost 2018; 18:437-450
Conway SE, Hwang AY, Ponte CD, et al. Laboratory and clinical monitoring of direct acting oral anticoagulants: What clinicians need to know. Pharmacotherapy 2017; 37:236-24
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